What is Diabetic Nephropathy?

Diabetic nephropathy refers to diabetic glomerulosclerosis, a glomerular vascular damage-based diseases. More than early asymptomatic, may be normal or high blood pressure. Measured by radioimmunoassay urinary albumin excretion> 200 micrograms / min, this period is called occult renal disease, or kidney disease early. If the positive control of hypertension and high blood sugar, is expected to improve lesion. If poorly controlled, with the progress of disease could be developed for clinical diabetic nephropathy, when the clinical manifestations can be the following:



1, proteinuria


Started as a result of increased glomerular filtration pressure and filtration membrane charge changes, urine microalbuminuria only there for the selective proteinuria, there is no increased globulin, sustainable for many years in this state. Glomerular basement membrane as the filter holes increased macromolecular substances can occur through non-selective and clinical proteinuria, with the further development of lesions, urinary protein gradually become severe persistent proteinuria, if more than 3 grams of urinary protein / day, the signs of poor prognosis. Proteinuria in patients with diabetic nephropathy the severity of the mostly sexual development until emergence of nephrotic syndrome.
2, edema

Patients with early diabetic nephropathy in general there is no swelling, a small number of patients with lower plasma protein in the former, may have mild swelling, when the 24-hour urinary protein more than 3 grams, the swelling will appear. Obvious systemic edema, found only in the rapid development of diabetic nephropathy are.


3, high blood pressure


High blood pressure in patients with diabetic nephropathy in common. More serious kidney disease with hypertension, and high blood pressure can accelerate the progress of diabetic nephropathy and deterioration. Therefore, effective control of hypertension is very important.

4, renal insufficiency



Once diabetic nephropathy, the process is carried out in nature, azotemia, uremia is the ultimate outcome.



5, Anemia



Marked azotemia of diabetes patients may have mild to moderate anemia, with iron therapy. Anemia due to erythropoietin barriers may limit the protein diet and long-term, azotemia related.



6, other symptoms



Retinopathy nephropathy is not performance, but often at the same time the existence of diabetic nephropathy. Some people even think that, no diabetic retinopathy, diabetic nephropathy could not exist.